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Microphonics on the E4 are well controlled in my opinion, I can walk around and move my DAP around without many problems. Only real problem till now was brushing my teeth with the E4s in place (I know, I'm crazy...), especially the teeth in the lower jaw proved problematic

 

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One think about E3 that has been mentioned. Their sound depends a lot on the tips you are using. The soft silicone tips give a bass light sound. With the foam tips however these things really start to sing. The bass is there and is quite deep while the high end ramains clean and clear. I haven't tried E4c (yet) but I'd say for everyday use in a noisy city environment they are very good, much better than anything else from Sony, Sharp and Panasonic.