I've owned a bose wave cd/radio for 4 years now. I have to admit that when I first heard it, it was really good, but less than stellar for its price. You'll probably can get a better, more powerful system for the same price. The thing to remember though, is that you are paying for its small size too. You'll probably never find anything else so small and non hi-fi looking that sounds to good.
THe CD/radio doesn't handle all kinds of music equally well. But I can say that its handling of small jazz ensembles is excellent and very impressive. Trebles are clear and and the bass tight. It is no surprise that Herbie Hancock does their advertisements on TV. It slightly falters in the area of clarity when there are too many sounds playing, like in an large orchestra. This is probably because its sub-woofer and and tweeters feed the same reverbation chamber. Its does very impressive mid-bass, full of reverb and visceral punch. Sub-bass is lacking somewhat and stuff like techno does not do too well.
Amplification will be limited for those how like their music loud. Distortion sets in at around 75%. And positioning is also stricter since the left and right speakers are so close together. It has a line in and line out. I place it on the shelf above my laptop, slightly higher than my ears and about an arms length away. I have no amplification problems at that range. Its connected to my laptop so I can play mp3s from it too.
Fortunately, its is quite easy and rather cheap to circumvent the Bose CD/radio's weaknesses. My recommendation is to connect a amplified tweeter-subwoofer sound system to the cd/radio. The Altec Lansing ACS45W is a good choice because it looks similar and is not much more powerful than the cd/radio. It is a good mix, because the atmospheric, expansive sound of the cd/radio is balanced my the more precise tweeters of the acs45. And its weak sub-bass is nicely filled in by the sub-woofer. The wider placement of the tweeters of the acs45 will give you a much better soundstage (best when placed to bounce of the walls). The only inconveniece is that you now have two volumes to control and balance (the acs45 is louder than the bose). I checked online and the acs45w can be purchased for about US$50 at computerhq.com. Acs45 appears on ebay for about $25 to $40 used.