Well, I've got er4ps with the s cable, and I like them a lot. They sound great and they isolate very well. In the noisy place I work, that's important. (And they don't make my whole head overheat like big closed cans do.)
I will say that the tips may make a difference in sound, but they also are a huge difference in comfort. I couldn't wear the white tips at all; they're painful and seem to pinch the insides of my ears. I could get a seal, but they were not comfortable, and no matter how good they sounded, having my ears hurt that much was not worth it.
The foamies, on the other hand, were comfortable and sound very good. Lots of folks here seem to dislike the foamies but, for me, they're the right answer.
I'm considering other cans to try at the office (less isolating) or for listening to music (open) but the etys are great.
(My roommates laugh at me when I play computer games. I'm not that great at them, but with a moderate sound card and the etys, I spend a lot of time just listening to what's going on around me. More important in sneaky games like Thief or Deus Ex than some.)