The HM-801 now has several amp options. I have the original version 2 card (designed primarily for full-size cans) and the GAME card (designed for IEMs). The ES5 are extremely sensitive, so even with the GAME card you may hear a little hiss at low volume and get some channel imbalance in the volume range where most people would feel comfortable listening.
Aside from those issues, I find the amps to be pretty good. They basically complement the HM-801's warm and fun sound; for example, piano chords have a very lush, if somewhat unfocused, sound. When I want more clarity and/or neutrality, I use the lineout to my Pico Slim.
I haven't followed the HM-801 amp developments that closely, but apparently a balanced amp card is coming out soon too (that's mostly of interest to full-size can owners).