I have Grado SR325 (original, not e, i, or x) and they are not nearly as comfortable and more mids-centered than the ATH-R70X. If I do a bass frequency sweep from audiocheck.net, some bass just isn't there.
The Grado SR325 are fun for rock. But for analytical music like jazz and classical -- and for long listening sessions -- I prefer the ATH-R70X. For what it's worth, if there are any other sentient beings living with you, for others in the room the ATH-R70X are also a little quieter than the Grado at the same listening volume.