UM2 to ES2 is a night-and-day difference. I can't speak for the UE 10 Pro, but the ES2 basically fixes pretty much everything that's wrong with the UM2, and adds significant amounts of detail.
The ES2 is the first IEM that I've seen that is tonally balanced. From what I've read, I expect this is true of other high-end customs here as well. Every universal-fit IEM that I've tried has tonal deficiencies - recessed trebles for the dual-driver models, lack of deep bass and a harsh lower treble for the single-driver models. I expect that the Shure E500 will be the most balanced universal-fit IEM on the market, based on what I've read anyway, but until it comes out, there is no universal-fit IEM, at least in my experience, that manages to get tonal balance right. On top of that, the ES2 is more resolving than the Ety ER-4S, since it's resolution is uniform across the frequency spectrum, while the Ety has a very resolving treble and midbass but not very resolving everything else.
I would say that the jump to customs is worth it if you cannot wait for the E500. I would hesitate to recommend the E500 unconditionally without having heard one, but I would also hesitate to recommend customs unconditionally, since they have absolutely no resale value. If the E500 can offer comparable sound quality, it will seriously undercut custom-IEM sales here on head-fi. I doubt, though, that we at head-fi contribute in any significant manner to overall custom-IEM sales.