Sorry to bring up an old thread, but better than creating a new one.
I'm having the same issues outlined in this thread. I have figured these things out:
1) It is not a software problem, it is definitely some sort of ground-loop problem with the USB.
2) The Fubar DAC is not grounded to wall (no ground pin on wallwart), the chassis isn't even conductive (and the circuit ground isn't connected to it), it cannot be used as a general ground point. In my setup, computer and amplifier are grounded, and plugged into the same power strip.
3) When the DAC is plugged into my laptop, there are no hums and everything is awesome. My laptop does not have a ground pin on its AC adapter. However the moment I plug my firewire cable from my desktop to laptop (creating a ground loop), the DAC loses signal lock (replugging it in fixes it).
4) When connected to my desktop, all hell breaks loose. I get the same static background as mentioned by GuffMorgan. This static can be removed if I unplug & replug the usb cable, however the static returns after a few minutes (randomly). Occasionally it is even worse, the DAC loses its lock and all you hear is static (and often startles me when I have a loud song going).
5) When connected to my desktop, I get a 60hz hum from my amplifier only when the USB cable is connected (does not exist on my laptop). However if I jump the ground pin of the USB cable to the ground of the amplifier, this hum is removed. There still is locking error with the computer, however it may be less severe (it's hard to quantify). I can also remove this hum if I lift the amplifier from ground, but locking issues are still prominent.
What to do, what to do... I'm thinking I should connect all grounds of everything - computer chassis, DAC circuit ground, amplifier ground - together and hope for the best. However suggestions from more experienced people would be great.