I did benefit a little SQ improvement pairing E1 muses too hometheater amp speakers, I agree with Manko it really depends on a number of things, eg:- the dac on my Sony TV isn't as good as the dac out of my HDX-1000 Networked media tank, or Apple TV, but putting them through the E1 muses gave better SQ, 2 channel only of course
However, I've come to learn this also depends a lot on what your dac was ultimately design for, E1 muses excels more with headphones rather then speakers, and my Femto dac is the other way round
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However, with this in mind I will answer your question, If we are just talking "SQ alone" E1 muses to "my ears" is the best dac/amp combo I've heard under 2k which means you won't have to pay 2k, but you will have to pay over 2k for a better sounding dac/amp, other dac/amp combo's I've auditioned that I didn't think had better SQ over E1 muses were Fostex HP-A8C, Grace M309, and Burson HA-160d