I had the opportunity to use a Xonar Essence One Muses Edition here at home and compare it with my HDVD 800, using both my speakers (B&W CM 8 with two subs) and HD 800. I never used the headamp on the Essence One, instead I connected it via XLR to the balanced inputs on the HDVD 800 and used the amp section with my balanced HD 800 headphones. The RCA outputs on the Essence One were connected to the Main In input on my Nad C 375 amp, so I was using the Essence One as a pre-amp for my speakers.
The difference between the two dacs was quite big. The Essence One Muses Edition had a thick bassy sound that seemed to emphasize instruments and visceral impact over vocals and neutral balance. It wasn't a slight emphasis either, as it was hard to make out what vocalists were singing in some parts with the Essence One, while the HDVD 800 dac presented the songs much more clearly. I'd describe it as the HDVD 800 presenting the sound with neutral clarity and precision, while the Essence One instead presented the emotional intentions of the artists.
There's no doubt I enjoyed the music more with the Essence One, but also no doubt that I could hear much more clearly what was going on with the HDVD 800. The Essence One sound didn't seem sloppy or anything. It sounded more organic and in most cases more natural, even if it clearly wasn't neutral. The HDVD 800 dac sounded more "digital", or I guess more like a scientific instrument than something made to enjoy music with. In almost all genres the Essence One was more fun to listen to, while the HDVD 800 just seemed a bit boring in comparison, even if the mids and highs were presented with more clarity. I'm tempted to get a Essence One Muses Edition now since the style of sound was so different from the HDVD 800 that it'd be fun to have both flavors of sound available to listen to.