I went ahead and re-bought the HD280's a few days ago and have been burning them in 24/7 for the past 3 days straight, I'm at 72 hours right now. They are sounding very good, I've been running them in at very loud volumes (just a couple of notches below where I hear distortion) with very bass heavy music, and they are further along after 72 hours now than the last time I owned them and had run them in for about 120 hours.
I also experimented with the blu-tak mod a bit - I noticed there was a tiny bit of space I could stuff some cotton in there in addition to the blue tak, I figured this might make them less nasal during the burn in process. I was right, with the cotton, no nasality at all. But pretty much all the high frequencies and most of the mids were gone too
And the bass was just WAY too overpowering BOOOOOMMMM BOOOOOOMMMM BOOOOOOMMMM. So, out comes the cotton! Ah, that's much better. They are sounding very nice right now. Almost as good as my friends sounded, but still not quite there yet. Perhaps I just did not burn them in vigorously enough the first time and that's why the nasal quality took so long to dissipate.
Anyway, there is still a bit more burning in to do, but I'm pretty confident it will be complete at 200 hours of VERY loud, very bass heavy music.
And, just a bit of a mini-comparison, I've been A-B'ing the 280's with my Beyer 250-250's tonight, and at this point I'd say the overall quality is a draw. The 2 have very different sounds, the 280's being a slightly darker, more intimate, richer sounding headphone with stronger and deeper bass, while the 250-250 is a bit brigher, more energetic, lighter in the bass, but more textured and detailed. With vocals, the 250's have a slightly artificial quality, while the 280s make all the female singers sound like they are sorta coming on to you.
For an absolute reference, the HD600's have most of the strengths of both headphones, with few of their weaknesses. Deep, strong, and tight/textured bass, detailed mids and highs that are not aggressive, able to present ambiance better than either the 250's or the 280's.
But of course the 280's still have over 120 hours of breakin to go, so I'll re-compare in another week or so.