I found that even after I bend the headbands on the 600/650, it would still hurt my jaw after half an hour or so. One problem with them comfort wise is that I find there isn't enough vertical and horizontol swivel on the Senn cups, so it's quite hard to divert the clamp away from my (what is apparently odd shaped) jawline. I wish I could turn the earcups a little more to the rear, but the horizontal swivel is only about 10-15 degrees with these and that's not enough for my jaw. The cups also don't have enough downwards swivel which puts additional pressure to the bottom of the jaw. I know Sennheiser probably designed it this way so that it seals tightly, but it really allows for very little room for cup movement which can be uncomfortable for some (like myself). But the biggest reason for my discomfort with these was that the oval cups of these headphones just lined up poorly to the most sensitive parts of my jawline, which is why most headphones with oval shaped earcups hurt my jaw (headphones like CAL!'s, Sony 7506, Bose AE etc are exceptions as their cups are much smaller and have very little clamp)... the big circular ones like the AKG's etc don't and I find them much more comfortable, even though the clamping pressure itself isn't actually all that less.
It's real unfortunate since I probably would have stopped my journey in this hobby with the HD650 since I do REALLY like their sound that much. Instead, I currently have to live with the MA900 as its somewhat similar but technically inferior alternative (that's not a slight on MA900, I do love them for what they are also, but technically they fall short of the Senns IMO). One day I may look into getting these and do some heavy modding to get these as comfortable as I can...