If your motherboard has the new bios 1.2.0.8 Agesa available I Would try that. Updating to the Bios in combination with disabling the power savings for USBs has resolved all of my disconnection issues. Been going strong for the last week now with no drop outs.

Damn..... I am indeed on a 5900x and using pcie 4.0 for my motherboard....

I too have been getting disconnection issues with my unit. I have tried swapping out different usb cables, and power bricks, as well as making sure that the usb is plugged into its own usb hub without other connections on the same controller to avoid any interference with other things that are...