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I was actually referring to my SM3's. I think probably the first and most fitting comparison I came up with when listening to them was a less detailed SM3.
Between those two it's definitely preference. They just have totally different presentations. They're pseudo-equals, with HD650 being the technologically superior one by a hair, but not so much so that it should trump preference in signature. Lots of people prefer HD600 more. It's the flat neutral one that was designed for classical engineering.
But people who love the warmed, mid-centric HD650 sound love that sound. It is actually highly detailed but the mind associates detail with treble sparkle, and the absence of treble sparkle tricks one to believe it's missing detail when it really isn't. Your signal chain is Bifrost & Lyr so you shouldn't be lacking there! But you have to adapt your brain to it a bit. Since you have them, listen closely and pay attention to the detail. It's there.
Of course it doesn't have that huge v-shape "fun" curve that your UE IEMs have. The polite, "refined", mids centric sound of HD650 is the opposite of a "fun" curve. HD600 is relatively flat (right between fun and refined) Nothing has as deep a V curve as Ultimate Ears, their house sound is as "fun" as it gets. By contrast Shure SE535 is what I'd consider the IEM version of an HD650. A little more "fun" but not much more.
I was actually referring to my SM3's. I think probably the first and most fitting comparison I came up with when listening to them was a less detailed SM3.