Yeah, what LFF said. Interviews, reviews and stuff like that. It doesn't have to be specific to this site, because it wouldn't be an official head-fi podcast, unless we ask for permission. It would basically be intro music, contents, some audio news, maybe a review, short interview and read out some letters, maybe answer some questions, then outro music. Maybe 30 minutes long and done regularly; such as once a fortnight. It would need two or three people to host it, it can be recorded over skype so that they don't have to be in the same location. The people hosting it would have to be experienced in the headphone or audio world, so that they know what they are talking about.
If someone wants to do a rough pilot, go ahead and record it. Then we can listen, pick it to bits and go forward from there. Don't worry about the technical side of things too much, because it can all be worked out.