I had a couple U16's working i2s with various DAC's (Topping, Gustard and Audio-GD) and my solution to avoid unwanted noises was to set the player at a fixed PCM bit depth and sampling rate. Now using a U18 with Pegasus, working PCM is rock-solid with a JPlay dual PC setup (windows 10 and Windows Server 2019, AO).
I have only tried PCM, and playlists are always the same sample rate.
U18 here has absolutely no hiss, clicks, skips, delays, etc. and has been the most stable of the 10 or so DDC's I have used in a similar PC USB source configuration.
I did not compare side by side, but the U18 seems a bit more analytical to me, compared to the U16.
U18 isolation and clocking accuracy seem to be working as advertised. I have a bunch of USB fixers, and none of that stuff is necessary here. Also tried a LHY OCK-1 with a normal cable (not the famed Gustard C2), and thought the U18 internal clock was similar level (I currently am using a tube amp, so maybe some detail retrieval not available).
My next step with be the DI-20 DDC from Audio-GD, I am using a mains regenerator so should not need the HE version ...
I think I may be able to squeeze out some additional smoothness and depth from the Pegasus, or at least get an optional presentation and then chose the preferred voicing.