My highest impedance headphones are Beyerdynamic T90 with 250 ohm. Is it enough? Does it matter if balanced or SE mode?
When I first got my S17 I proceded immediately the burn in process, I grabbed my focal elegias and started playing music on them for several hours per day when I was out for work and I did this for about two weeks, the elegias I think are 32 or 35 ohm if I'm not mistaken and are pretty efficient and easy to drive on anything, that's kind of their appeal, closed back and all and pretty good sound overall, specially when you pad roll them with the dekoni sheepskin pads, they improved a lot.
Anyways, I did notice after that burn in that there was an improvement in the sound quality coming from the amp, but almost serendipitously my father got a pair of SEN HD650 and he didn't like how they sounded to him, I think that's mostly due to the fact that my dad almost exclusively listens to DAPs and portable equipment and imho, they do sound good coming from those sources, but your missing a lot of the full capabilities of the 650s unless you run them in dedicated desktop amps and you need to drive these cans hard to get the most of them, then those truly shine.
So I proceeded to adjudicated to myself those cans that my dad deprecated so much and started running them on my desktop setup and it was freaking awesome, and then after a week or so of listening to them, I went back to my radiance and my other cans and noticed that the sound had change, like substantially so, a lot warmer and lusher like other reviewers had said so in their reviews and it even improved my power speakers I have on my desk, it was amazing. This was after more than a month of running this amp, I never turn it off but at night when I go to sleep, I do put it in 50ma mode on low gain to save some power.
So given my own personal experience with the amp, I do recommend that you put a high impedance load on your S17, I think 250hm of you T90 should be more than enough, I actually recently bought a custom DT880 from Custom Cans in england with the balanced cable mod and some dampening in order to improve the sub-base because I now want to run a higher, 600ohm load on my S17 and see if the sound improves even further and in the future, if I buy another fully discrete, class-A amp, I'm planning on using those cans to do the burn in.
I do believe that this amp needs the work out in order to bring out the best out of it sound wise, your millage might vary tho and it might just be placebo effect in my case, but when I first plugged in my dad's HD650s I wasn't even expecting anything to change, I was under the impression that the burn in was already done and I was pretty happy with the sound from it and grown accustomed to it at that point.
And yes, you need to run them balanced in order to put the entire amp on load, if you run them single ended you're basically only running half the amp.