well, I know that FLAC is lossless, but some argue that with UN-compressed files, the player's processor do not have to uncompress. And therefore uses less processing power...
I didn't mean to imply you didn't know; I just like to be thorough.
It may be true that there is less processing involved, but it should be negligible, and there's no reliable evidence to support the claim that it is audible. Many players uncompress the data before playback even starts. You can also program some to store the data in RAM before playback. Either way, the bitstream is identical.
To test the claims of those you have talked to who say uncompressed sounds different, you can direct them to
this post and request that they follow the instructions there and share the results. (They would need to get at least 9/10 or 15/20 correct for the results to be statistically significant.)
Oh, and before that, they would need to convert the files themselves (not use files from different sources) with a high quality program like dBpoweramp (as well as making sure to remove any tags related to ReplayGain and DSP) in order to isolate the variables.
At any rate, what you hear is what's important. If you don't hear a difference, that settles the matter, I'd say.
A fun experiment you can do is to convert an uncompressed file to various bit rates to see where your threshold of audibility is. Take a WAV or AIFF file and convert it to various lossy (like AAC or MP3) files at 10, 20, 50, 75, 100, 150, 200, 360, etc. kbps. Then rapidly switch between the files in a music player. I'd bet you'd stop hearing a difference between the original file and lossy somewhere between 100 and 300 kbps, at least most of the time.