If you're looking for your first audiophile headphone for home usage, these may work well for you. The detail they offer is superior to mainstream consumer market headphones.
However, if you own and listen to high end gear, I would not recommend these headphones.
First of all, I disagree with the praise the Hifiman HE350 get for comfort: I found these very uncomfortable to wear because the pads are very hard. To make matters worse, changing the pads is a pain, because upon removing the stock pads, the plastic rings of my pair snapped because they are so brittle.
After re-gluing the plastic pad rings, I tried the following pads, which all had different effects to the music:
-HM5 Angled Velour: increased comfort drastically, smoothened the treble significantly, but they lost all their punch, making them sound very boring.
-HHM5 Angled Leather: increased the comfort as well, the treble remained the same but the pads increased the bass (because of the seal), giving the illusion of less treble. There was also much more punch.
-Hifiman focus pads: increased comfort, treble slightly reduced, slightly increased bass. Wider soundstage. Since they are a hybrid pad of velour and leather, they offer the best of both worlds. They also come with their own pad rings, so you don't need to spend hours trying to fit them on like the other pads I've mentioned. If you change the pads, I recommend you use these.
The mids I feel are reduced, but what I think is happening is that the harsh and abundant treble swallows the mids away. The Hifiman he-350 are awful with electronic music, making you want to take them off immediately off your head. With classical, they actually sound fairly good, but certain notes from violins and trumpets may sound too shrill.
I mentioned that the bass was fairly lacking in these headphones. To fix this, you can remove the outer rings to access the driver, and there's a sticker covering a hole in the centre of the driver. Move it down so that it no longer covers the hole, and put the cover back. The result is slightly increased bass, though I would still call the Hifiman he-350 bass-light.
However, after all this work and effort pad surfing and driver modding, I still do not like the sound they produce. If you're a mid-fi/hi-fi audiophile, you already have headphones that produce more detail, have a more smooth and less tinny treble and have more bass; but as somebody who has never bought an open-back headphone before, yes, I would recommend them since they are still an upgrade from your mainstream cans. The lack of bass may annoy you though.
