Short answer - No, sometimes, sometimes.
Amps sound different. The search is half the fun right?
I hate to be contrary, but when a cable is the right size, it is indistinguishable from any other cable the right thickness. Many high end cables goose up the capacitance to get sharper leading edges which can definitely make the sound be "crisp" or whatever the advertisers say. That'll change the sound fersure. It might even sound nice with the right setup. Some other cables are really nicely shielded and well built. That's worth a few extra sheckels and I'm willing to dish it. You can get those for a few bucks a foot at an electrical supply shop and they're pretty good stuff. Under a few feet for a passive speaker, it doesn't make a lick of difference what fortune you blow on cables. If upstream isn't up to snuff, the cable isn't going to fix it. If you really want your system to sound the best it ever will, solder your cables in. That or just keep everything molecularly clean and re-clean it every few years with the right deoxit. And keep your runs as short as possible. When you go long, you gotta spend the dough on heavy duty wire.
Power conditioning helps if one of 3 conditions is met - 1 - you have a lot of motors on your circuit (transformer on down). Brushed motors are the worst. Think cheap power tools, old fans, etc.
2 - your system has a minimum sized power supply. Minimal power supplies are endemic, so you would know better than I about yours.
3 - Your system has wall referenced voltages. This is really common in older units that were built before voltage regulators were made small (think tubes), DIY units, and cheap units.
If you have a lot of noise on the power line but a beefy supply and no reference voltages, then you don't need conditioning. Your P/S will do it for you.
I'm an electrical engineer and I work on audio electronics. I'm not just some crank who doesn't know what he's saying.