I am not turning off Wyrd when I am not using comp. But you can if you want - it is only a matter of convinience.
Talking about USB cables - yes they make a difference but Wyrd reduces the influence of USB cables. Shiit has a very good USB cable for 20 USD and I can highly recommend it. It stands proudly against some very expencieve and very good USB cables. It is really a great value USB cable.
PSU of Wyrd is not switching. It is linear supply based on LM723, which is according to Mr. Moffat, even better than the old LM317 reg. LM317 is a very good reg (used in such units like Naim and many others) and if the statement of Mr. Moffat is correct than there is no much to complain about. Of course that it is possible to make better linear PSU, using for example descrete shunt reg, but that will cost probably more than Wyrd itself.
I think Wyrd has a lot of sense for units like Shiit own Modi or Loki or if you are using something like Audioquest Dragonfly. I am not sure about more complex DACs, which usually already have a decent filtering at the USB input. That has to be checked first I guess ...
I have two pieces of Wyrd: one is connected to Win 7 machine driving Shiit Loki and the other is connected to Mac Mini driving M2Tech hiFace Two. I have them for about a year now and I can say that they are reliable units, producing no problems.