Still playing with all my Vyrus tuning options (so far most fond of the gunmetal) so my impressions are just that, preliminary impressions. The Vyrus is a cleaner, more balanced and detailed sound that therefore gives you the feeling of a wider, deeper soundstage. I think this would lead some to call the Vyrus analytical, but I just think of it as really well-tuned. The 4in1 is very musical with mids a bit forward. The treble and bass are nonetheless very good. Detail is present, but doesn't match the clarity of the Vyrus. This all makes the soundstage seem smaller and a bit more congested than the Vyrus on first impression but I think I'll ultimately come to see them a bit closer than that. They're really two very different IEMs that deliver different things. If I had to keep only one, it would be the Vyrus right now. Again, these are my current, initial impressions (e.g., I haven't even tried amping the 4in1, the Vyrus uses more power quite nicely).