I have a very funny shaped head, i.e., the top of my head is V-shaped instead of somewhat curved like most people's.

I own the Beyer DT250-80 and noticed them to be uncomfortable for the first week of listening, but now I have no comfort issues at all. After a month or so you'll be in love with those cans. If you wear them for the first time you'll notice they tend to rest on the top center of your head more than you'd like but you'll get used to it quickly.

Cheers,
Geek