I'm a relative newbie to the headphone game.
My reference system is a Burson 160D, and having a good reference is essential when you're comparing tubes.
My reference headphone is the Sennheiser HD 650, which are known for their veil until you put great amplification with them. I also own UERMs, which aren't appropriate for this type of listening analysis.
First out of the box I was quite unimpressed. The soundstage was decent, but not exactly impressive. The bass was muddy and shallow. More disturbing, is what happened to passages with a lot of reverb. The decay would clamp down hard, and you'd lose a lot of transients. I found myself running back to the Burson, wondering what I was thinking dropping $550 bucks on an experiment.

The photos on the web site of the Princess Sophia tube had me drooling, and I ordered soon. The upgrade piqued my interest as the WA6 began performing. It wasn't audio nirvana, but the soundstage improved and the bass opened up a bit. The Woo WA6 wasn't winning, but at least it was in the game. My trips back to the Burson were suddenly less frequent.
Reading another review here on Head-Fi, I read a lot of praise for a stubby, unattractive tube called the GZ34 made by Mullard. It appears the older you go, the better the sound becomes, so says the pricing and reviews on these short tubes. I found one on eBay for $120. A 1958, standard base NOS, and the WA6 was suddenly a force to be reckoned with.
The GZ34 launched the WA6 into orbit. I've yet to find a tube that can compete-- but if you're looking for a cheaper substitute, check out the CV593. They're lacking a little on the bottom, but match the GZ34 in most respects, and it's a much prettier tube, to boot.
On the drive side, tube after tube after tube sent me back to the stock RCA 6DE7. I still haven't found any worthy upgrade, though I'm currently testing a 6SN7 that's showing some promise. Woo claims the 6GL7 is the premiere tube for power on the unit, I couldn't disagree more, and I was sorry I flushed the $110 down the drain. While adding more drive, the GL7s added some distortion and crunch, and reminded me of an FM radio sound circa 1977. The lesson here is the rectifier tube makes a greater impact on the tonal quality than the drivers, so put your money in a good rectifier and be happy with the stock 6DE7s.
For intense listening, the WA6 now outperforms the Burson 160D. That's saying a lot. However I've spent hundreds and hundreds in tubes to get here. The Burson excels at everything and gives you a DAC converter and pre-amp to boot. It's a better buy.
If you like tweaking and hunting-- the WA6 can provide that rare audio nirvana we seek. But it's going to cost you and be prepared to roll through a lot of tubes before you find that ideal match.
A final word on fit and finish-- this unit is just beautiful to look at and built like a tank.