Winston brings up an interesting point about Flukes: accessories. The cynical will just say that it's a way for Fluke to get even more money out of you, but the fact is, it's nice to be able to get any type of test lead you might need and know that it will fit well with the rest of the meter. Some times this comes down to a real compatibility issue, like with a temperature probe. Other times it's more of a styling issue: Fluke's probes have exactly the right connector to fit in their meters' jacks, for example. I've used other banana plugs in my meter, and sure, they work, but not quite as well as the one on a Fluke probe for one reason or another.
Also consider fit and finish. Cheap meters come with cheap leads (PVC instead of silicone insulation, poor molding, hard feel, missing nice touches like a large safety guard near the probe tip, etc.), the knobs don't feel quite as good, etc.
Consider also service: Fluke can and will repair any meter they sell. Sure it costs money, but not as much as buying a new meter if you somehow damage yours or force it out of calibration. The new meters are even coming with lifetime warranties. (Limited, of course.) Lots of cheap meters can't even be serviced, either because they're so cheap that it's not worth it to work on them, or because the manufacturer just doesn't care to set up the necessary service apparatus. And here's a bit of comedy: Beckman/Wavetek/Meterman/whatevertheyarethisyear meters can be serviced, but guess where they send you for repairs: to Fluke! Even replacements come through Fluke!
Bottom line, no one in this business takes care of their customers after the sale better than Fluke.