No, I really don't EQ, but I have tried it a bit with the iTunes EQ on R&B. The bass really jumps out there, but I eventually went back to flat. I will state, however, that a good amp really pushes the ME.1 to its fullest potential I use a tube amp (Project Ember by Garage1217). The amp and earphone have great synergy.
Understand, usually tube amps are definitely warm and I’m assuming they can offset some of the lack of bass I was pointing out.
I sue my me.1 with the Wm1z this is where the main difference is.