Well I have commented on both of these IEMs elsewhere in these threads.
I find the TF10 to be a more balanced sounding IEM than the mid-centric SE530, with superior instrument separation and a noticeably larger soundstage. Its highs extend further. Its mids aren't forward, which translates as recessed for some people. I think it presents bass more realistically than the SE530. The SE530's bass is tighter but it doesn't go as deep to my ears, and it has a tendency towards sounding monotonal. The TF10 also has more clarity and is more detailed to my ears. I also think that despite its livelier treble presentation, the TF10 is a darker sounding IEM overall compared to the SE530.
I agree with Pianist that the mids of the SE530 are liquid. However, they sound enhanced rather than natural to me. The treble roll-off makes acoustic instruments such as piano, guitar and drums sound subdued or veiled. Fine details such as the shimmer of a cymbal, or the ring of a note from a piano key can be muted due to the suppression of high frequencies.
I don't find it plausible that this can be entirely attributed to poor fit, sound sources or recordings as Pianist suggests. That's just making too many excuses for the SE530's sound signature in my opinion. It is what it is. Some people love it and others don't. What some people describe as an easy, fatigue free listen, others regard as too polite or even boring. I happen to enjoy it and it does provide unparalleled noise attenuation.
I simply prefer the sound of the TF10 (and the IE8 for that matter) over the SE530. However, it's well documented in these threads that the fit of the TF10 can be problematic for some people, particularly if they have small ears. Fortunately, I haven't experienced this problem.
So that's my opinion for what it's worth, but I'd take it with a grain of salt if I were you.