I don’t think so. I’ve used FLAC, ALAC, AAC, and MP3 on mine. I’ve also done uncompressed AIFF and WAV. I think it plays DSD, but I don’t have any of those.Does Pono play ogg vorbis files?
one thing to note: gapless playback only works with lossless files. There’s a small gap you can hear between tracks when using MP3 or AAC files.