Interestingly enough, there's a somewhat similar thread here:
http://www6.head-fi.org/forums/showthread.php?t=105191
There's more than a few times where people refer to Ety ER-4's as "hyper-realistic", because it produces sound results that doesn't really happen in real life. There's a lot of ways to look at it, some would say that ER-4's treble seems sharper because of lack in everything else. Some will say the ER-4's treble simply is more enhanced and has more "tizz" on top. There are even people who said that you can't match the apparent detail of the ER-4 unless you go to electrostatic headphones.
In my opinion, a combination of a few of those factors give ER-4 this hyper-detailed, unrealistic sound, that once someone becomes accustomed to, will expect out of every single high-end sound experience. That simply isn't "correct". There are headphones that sounds natural, realistic, and portrays a more life-like and accurate characteristic than the ER-4 with significantly less treble reproduction.
2X-S is simply truer to the source, if the source doesn't have treble (whether that be the playback source or the recorded media), it will not accentuate what isn't there to begin with. ER-4 and UE-10 Pro will both enhance treble to a point where it was never really meant to be. It could even be argued that UE-10 Pro's treble will feel softer than ER-4's, because it does have better sibilance control (although not as good as 2X-S), and it has more other characteristics (decay, other type of microdetail, more bass) that makes treble not necessarily the only focus of the sound itself.
There's a lot of audiophile quality headphones that simply sounds "real", and that's a much harder concept to grasp and appreciate than tremendous amount of unrealistic detail or any other special characteristic otherwise.
There is an opportunity to get more treble in your 2X-S by using different opamps in your amp, or using different amp and source altogether. Using my iPod with my HR-2 against using my CE775 produces dramatically different sound, of course the CE775 have much crisper and better trebles, but that's simply because iPod doesn't reproduce that.
You might also consider file format, are you using lossless encoding with your iPod? Or are you using MP3 compression? Often lossy compressions will cause you to some of the expanded dynamic range in either treble or bass regions of the music, and you might not have found it that way because ER-4 stretches the treble anyway.
In the end, the main point is that the ER-4 sound isn't "real", and people who gets accustomed to that and think that should be the expectation of all high-end sound is really misled. I think ER-4 has its merits in its price range, and it made obviously sacrifices to provide an unique experience; but it is by no way, anywhere near a "reference" and "neutral" platform for sound reproduction.