ProPhonic 2X-S is consistent in its sound signature and delivery, you don't really have to worry about what to pair it up with.. It'll sound good out just about anything. Of course it'll sound better out of certain set-ups as opposed to others, but that's really personal preference of a particular type of sound quality and sound signature "tweak" you want to achieve.
So questioning synergy is really.. well... not an issue you should be all that worried about.
Furthermore, the 2X-S is probably going to be so much superior than everything else you've got anyway, you wouldn't even know whether or not you've achieved the "maximum potential" of it all anyway.