Personally if I could make things sound how I want with software, I absolutely would - more precise control of bands, no dealing with interference noise, and save myself hundreds of dollars
In my experience I tried this. I really did. I sat around and fiddled with knobs on my Loki+ until it got where I was happy, then bypassed it and tried to fiddle with EQ sliders until I was happy. Hours later, A/B tested and there was no comparison, my "best results" on software (that I thought sounded good for hours) sounded awful and hollow compared to the Loki. I tried to re-create the settings on the Loki but with different Q-factors it would never be identical so settled for doing what sounded best to my ears. (eqMac on MacOS allows control of q-factor and every band you can think of, but its a monthly subscription so hard pass for me)