Slaphead
500+ Head-Fier
Yeah, within a PC you've got a ton of stuff that's creating HF interference. PSUs VRMs CPUs GPUs all create spurious HF interference, and a lot of this ends up being transmitted through a USB (or another electrically conductive cable such non optical S/PDIF) and that permeates through whatever DAC you are using thus leading to the glare that can be heard. Even though the RME is very good at signal rejection it will succumb to excessive amounts of HF interferenceDoes your computer have optical out?
I'd been using my RME-ADI 2 via USB with a Lenovo Tiny PC, no matter what USB port I used the treble was harsh and there was a metallic shimmer to the sound (but no drop outs), but when I used my old Galaxy Note 5 with an OTG cable the problem was absent. Because my little PC doesn't have optical out I purchased this USB to optical / coax converter, it completely solved the problem, now I run the RME via optical entirely, and IMO the sound better than USB anyway.
https://www.ebay.com.au/itm/392866127540
However this is somewhat dependent on the quality of your hardware. If you use a cheapass PC then you're more likely to have a problem than if you got something a bit more pricey. That said there's variability even at the high end of the PC market.
So, for computer audio it often makes sense to use the optical output, or use an optical converter to get the best out the DAC.