I can recommend the following titles -
DisneyWar James B. Stewart
History of the World J.M. Roberts
The Genius Factory David Plotz
Assassination Vacation Sarah Vowell
The Partly Cloudy Patriot Sarah Vowell
Buddha Karen Armstrong
Stiff Mary Roach
His Excellency Joseph J. Ellis
Salt Mark Kurlansky
Reefer Madness Eric Schlosser
The John Updike Audio Collection John Updike
The Culture of Fear Barry Glassner
A People's History of the United States Howard Zinn
Lies and the Lying Liars Who Tell Them Al Franken
Middlesex Jeffrey Eugenides
The Promise of Sleep William C. Dement
Benjamin Franklin: An American Life Walter Isaacson
A Short History of Nearly Everything Bill Bryson
The Crisis of Islam Bernard Lewis
War Letters Andrew Carroll
Live from New York Tom Shales and James Andrew Miller
Bush at War Bob Woodward
Seabiscuit Laura Hillenbrand
The Old Man and the Sea Ernest Hemingway
Me Talk Pretty One Day David Sedaris
1776 David McCullough
Europe's Last Summer David Fromkin
Also This American Life and X-Minus One episodes can be great to listen to on the road.
EDIT: And consider
Audible.com (or thru iTunes) if you're going to plow through lots of titles.