Well, having just picked up both, I can offer my thoughts...
The 325i is definitely more forward. I find it too bright w/ my PPAv2, OK with my friend's M^3 and fantastic with the Millett Hybrid prototype I've been using. I never understood what people meant by the "speed" of headphones, but now I do and the 325i is amazing in this respect. The detail is great, and when paired with the right amp, the can really shine. Personally I prefer these with Male vocals and guitar-driven music. Female vocals, even with the tubes, sound a little thin, and piano lacks any real impact.
The 650, while laid back, was a pleasant suprise in the sense that I find more detail in the high-end than the 580's they're replacing. I didn't find the treble roll-off I had read about so often on the forum. These phones are SMOOTH while still maintaining a high level of interest. I'm amazed people call these cans boring. While not as lively as the 325i's, they're very engaging. The midrange really shines, giving me an excellent option for female vocals. These pair really well with my PPAv2, sound good with the M^3, but are a little muddled and uninteresting with the Millett.
How all this relates to using a receiver headphone out, I don't know. But both cans can shine when paired with the right source and amp. So if you like the Grado sound, that might be a better option, knowing you can upgrade your amplification down the road.
HTH,
Ian