Yup, I saw it coming after the first time I found one of my monitor in my pants. The 2-pin is shi-te if it becomes lose fitting, and it does with time. So I took extra precaution until I upgraded to the Roxanne.
If you have unlimited funds then anything goes, but understand that there are severe diminishing returns past the $1500 mark. The layla does not sound anywhere near twice as good as the Angie, and you could easily save the money for another CIEM in the future when something else revolutionary comes along.
But just so we're clear, I came down the same upgrade path as you, and if you like how the 16s sound you will want to go with the Siren series as it's the only CIEM that can be tuned (without resorting to EQ) to sound like the 16. No other IEM can deliver that much bass, mostly because it's, well, just too much
Anyway, plenty of good sounding options on the market, just depends what features are relevant to you.
K10 - amazing workmanship on the shells
JH - secure cables and adjustable bass
1964 - adel technology
Westone - silicone canals for better comfort and isolation
UE - 3D printed shells should provide a better fit, in theory
There are many more but I can't list them all. You can see each manufacturer has an ace up their sleeve. They all sound good, none of them sound bad, at this level it really just depends what other features you want.