Yes! My X20U on Win10 Pro64 can do DSD64 and DoP. I do not have DSD128, but according the the spec, it will work as well. I have also tried a 64 bit 192KHz wave file over USB, it also works beautifully, even though the spec did not mention 64bit file at all! Foobar says the file is 64b/192KHz, so I hope this info is genuine!