"Brain burn-in" couldn't be easier to mitigate in all cases that burn-in is mentioned. I this case, just don't listen to it while leaving it on with bass boost on as well for two hours. Besides "psychological tricks" don't work forever, experience is another "mitigator". I've read people say stuff like, "all the detail you hear is in treble boost"; but again, a little experience with a diversity of equipment and playing around with EQ breaks such illusions easily.
If you really want to hear the difference (often small anyway) from a more "objective second opinion", grab a new amp, immediately record the output with a Komplete Audio 6 and some music and bass boost off, then burn in the bass boost, then rerecord the same music with bass boost on, then you'll have a very reliable second opinion.
Simple as that. ADCs can hear most of what we ourselves can, in my experience, even stuff you wouldn't expect them to.
Bass boost is not only dependent on the design, but also the headphones. All of my low-impedance full-sized and on-ear headphones (bunch of sennheisers, Koss, Beyerdynamics, AKGs, and a Grado) respond well to the bass boost in my FiiO E18, xDuoo XD-05, and a FiiO E17k I sold off. Modest bass boost without compromise. Too bad that I don't have a Q5(s) myself to check how good (or not) its bass boost sounds. It seems that other FiiO products got worthwhile EQ effects, especially the E17k.