For single player support I have no doubt, but multiplayer split screen not so much. We had difficultly with the split screen and only one of the controllers would work sometimes. Also certain button controls for the second controller where different. It was just a mess. We eventually figured it out but it still was a pain since we had to play around with the settings every time we would restart the game.The console was smooth. You simply turn on the second controller and BOOM, you play, No fuss. PC it is a bit more complicated with patches and settings. Single player on the other hand, for PC left4dead 2 had so many add-ons and other cool content, it was pretty impressive.
PC isn't more complicated with patches, since like console it's all automatically downloaded in clients like Steam and Origin, and you can actually disable automatic updating too. And as far as settings go, you don't have to tweak them although it's of course best. If you don't, you'd be left with the same settings as console, except for graphics settings which depends on your hardware since they auto configure.
But I suppose issues with split screen aren't as surprising, since split screen is mostly a console thing. Although bugs in Valve games are extremely rare in general.