I don't know about the HD 380, but I will say that Grado headphones are among the best overall at musicality and tonal balance - don't buy the myth that they're only for rock and roll. Having said that, they do very well with rock and roll. Comfort is a bit touchy to describe - I think the SR-325 are too heavy and sound too bright, but found the SR-225 to be perfectly comfortable, and I regularly wear my RS-1 for hours and hours on-end (like any other headphone).
Tell me what you're planning on plugging them into, and we'll talk about amps.
As far as other open-back headphones that will do good with rock or overall, will lead you to the Koss ESP/950, AKG K701, Sony MDR-F1, and perhaps the Ultrasone PRO2900 or HFI-2400 if you don't mind the extra bass and treble (in the case of the 2900).
Closed-back is a bit more contentious - I don't like a lot of closed cans, because a lot of them do something very wrong. The Kenwood KH-K1000 are probably my favorite, and do everything well, but are somewhat heavy. For less money (and less weight), the Bose QC15 aren't a terrible choice to look at, the same goes for the Sennheiser HD 280 and Koss R/80. The Denon AH-D2000 were/are (they're being closed out right now) also worth looking at, but availability will probably be a problem moving forwards.
And before you say anything about prices: yes I realize the price-range of the models I just mentioned is literally all over the place. Price doesn't correlate to performance in absolute terms.
EDIT
Just saw the full title in the URL - you mentioned an iPod touch (it's also "their" not "there");
Of the models I suggested/mentioned:
The Grados will have no problem, the same will hold true for the Denon, Kenwood, Bose, Sony, and Koss sets, the Sennheiser and Ultrasone sets *should* do fine, but I haven't ever confirmed. The AKG will very likely work fine, but I'm maybe one of four people that will tell you that, so be prepared to be sold on an amplifier.
With the Koss ESP, I would suggest an LOD to feed the E/90.