USB cables can make a difference to the sound - not due to source jitter (as this is completely removed by Hugo), but due to the amount of RF noise that gets injected into the ground plane of Hugo. More RF noise, more noise floor modulation, which makes it sound brighter. Unfortunately, I suspect some expensive USB cables actually make RF noise levels worse, so it will sound brighter and give the impression of more detail. So my advice is to be careful if it sounds brighter!
Another issue is signal dependent ground currents that are distorted - these currents come from the source when processing the data - but the cable can't do much to change this, as it is a low frequency error. Galvanic isolation can be made to work to solve both the RF noise injection, and the distorted signal dependent ground currents. These ground currents affect sound stage depth, as the corrupting signals are at their worst when the data crosses through zero, as all the bits switch from all 0's to all 1's and vice versa - so it degrades low level details, which are the cues for depth perception.
Rob