All of the Grado ear pads are interchangeable. There are three types. I think it will depend a lot on your ears as to which will be more comfortable. Ear Zonk makes ear pads for half the cost and you can get them on Amazon. They aren't identical to the Grado pads though, and their quality is probably not as good.
You can also easily stretch the headband out a bit if the pressure on your ears makes them uncomfortable. They are a bit tight out of the box, but it's not an issue after you adjust the band.