I am wondering if there is a noticeable difference between Lossless and 320 kb mp3s or 256 kb aacs with some of the lower end yet still audiophile headphones such Focal, Akg and Mr. Speakers mad dogs. When I say lower quality I mean around 500-600 dollars and I know less expensive does not necessarily mean lower quality however I do feel that with a lot of headphones the price is a decent representation of sound quality. I mostly use 256kb aacs and I do not really like lossless because a) takes up too much space b) not as big of a selection for some genres. I listen to pretty much everything. I am also a musician and am told I have good ears.