Sure. On my Mac I right click on the desktop to create a new folder. I name it whatever I want, artist/material. Say, for example, Neil Young Various. Then simply assemble whatever music files I want in a 2nd folder, until I have what I want. To get the order I want, I renumber them so that they line up correctly. Then I open XLD, a free Mac sourceware app, go to Open Folder in it, open the folder with the music files, put an appropriate picture in the box so that each file will have the same picture (say, in the case above, Neil Young). Then I go to Edit Metadata in XLD and I... edit the metadata so that each file has a name and an artist, nothing else. I check the box for Compilation, though you don't need to do that. Then I run Extract on XLD using the FLAC setting and it creates, in 01, 02, 03 order, my files, each properly tagged and with a picture embedded in it (I point it to my Neil Young Various folder, so all go to that folder). When done, I open the folder and take out the log file, then simply drag and drop it into my SD Card. Pop it in the DX50, it scans, and Bob's (well, in this case Neil) my uncle.
If you use a PC (my condolences), the procedure should be the same, with a different app. Pretty simple, really. The only issue is that, unlike an iPod, the playlist file is an actual file, with size, not a phantom playlist with no size. But with big SD Cards, that's really no issue.