In short yes definitely. I recently purchased an Asus Xonar Essence ST to feed to my Sennheiser HD380 PROs. I use my computer for everything from listening to music through ITunes, Pandora, and GooglePlay music, I play PC games like BF3, Tomb Raider, Skyrim, Diablo 3, and also play blurays quite often. First let me share my setup as everyone's is different.
Custom PC: I5 3570K, MSI GTX 580 GPU, H77M MOBO, Rosewill Thor V2 case, Rosewill Tachyon PSU, Asus BD, 4 HDDS including SSD for OS (win 7 64), Gskill Ripjaws 8 GB CAS.7-8-8-24
Desktop Speakers: Bose Companion 2 (nothing special)
Headphones: Sennheiser HD555 and Sennheiser HD 380 PRO
Audio Interface: Focusrite Scarlett 2i4 (previously used Asus Xonar Essence ST for my audio needs)
Every Single Game, Movie, and music that I have heard with my through my HD 380 PROs sound so much more lively, realistic, detailed. It reminds me of years back when I had my power amp and preamp separate's powering my B&W 705's. It was musical bliss. In the last year I've become a father and moved back to my home town, and in the process sold all of my gear (talk about regrets). After giving custom built computers a try I finally got to the point were I wanted audiophile quality back.
I read reviews on different sound cards and amps and finally decided on the Asus ST. Got it installed plugged my headphones in. Wow what a difference compared to onboard audio. But being an audiophile I decided to try an audio interface (preamp). The amount of detail that the Focusrite oozes so easily is astonishing to me. It's about the same price as the Asus ST but it on another level. I now find myself actually enjoying and getting drawn into the music again, and watching movies is a totally new experience! Audio should get you completely enthralled into whatever your listening to or watching. Somewhere down the road I forgot about that. I'm glad I found my way back. Even my wife was impressed and could tell an immediate difference (That's always a good thing).
I highly recommend the Focusrite Scarlett 2i_ and the Sennheiser HD380 PRO headphones. I am confident you will be hardpressed to find a better combo for the price of both the units. The HD380s are one of the best headphones I've heard at anywhere near this price point.