I'd add the TS-400's to that tip list as well.
Can you point out what part of the design has been ergonomically designed to be worn cable up, 'cause I can't see it.
With that being said, I do get a better seal when wearing them cable up. I have no idea why though and can't see anything in the design that would cause this to happen, so I just assumed that it has to do with the shape of my canals and the angle in which I insert them.
IMO, these weren't designed as reference... A reference IEM, RE272, Etymotic, DF-comp IEM will sound well too bright for modern recordings. These were designed to listen to the recording without hinderence, fatigue, or anything of that nature. Hence the warmer overall sound, it is forgiving as it filters out some of the garbage that is present in many tracks nowadays.
+1 I still have an RE0 and compared to RE-400, I think RE0 actually has more detail and clarity overall. RE-400 has better dynamics, somewhat better presence in the deep bass and a more 3D soundstage. For acoustic music which I listen to a lot, RE0 is the better choice with its higher fidelity IMO. For pop, rock or dance, RE-400 does better. I really wish Hifiman kept the RE0 too!