Or if you wanted something even more powerful try Traktor. You can get a copy free with the $100 dual channel NI Audio 2 DAC.
iTunes drives me nuts, I can't flow with the interface I'm constantly trying to figuring out how to do things and where things are. Honestly playback seems pretty poor on sound quality as well like certain ranges are omitted and others are exaggerated. As a result I'm doing Apple Lossless and Windows lossless too. When I find a player that manages music better I'll stick my library there.
I'd also put my hand in fire that Jriver sounds better than Foobar. I don't know why. I didn't do a blind test, but somehow it sounds nicer. If I compare the songs side by side, I FEEL like Jriver's soundstage is slightly more natural, with more depth. Simply, it feels like there's a slight crossover turned on, but its not, its all turned off.
Foobar uses less ram/cpu than itunes. tons of features, its very fast and customizable.
I also made the switch from itunes, and i don't want to go back.
I've always hated iTunes so I don't use it much more than to sync my iphone for updates and to manage music on the phone. Foobar2000 is a nice player once you overcome the customization learning curve, and there are some nice configurations contributed by people out there that make it very usable and visually pleasing.
Ive gone from winamp Pro with Wasapi plugin to AIMP3. I dont know if its placebo, but I belive that AIMP3 sounds a little better. Little more clear and "natural".
I cant get foobar2000 to work with wasapi plugin, but foobar also sounded better then winamp
On my MacBook Air, I generally just use iTunes, but I'll switch to Decibel when playing 24/96 content. On my PC, I use Foobar.
Sound quality-wise, I don't hear a difference between the different applications, but that's to be expected.
I have tried Decible, Pure Music, AudioNirvana, IRiver and Amarra is -by far- my favorite player. The sound is just more natural and transparent to me. Pure Music in particular felt too harsh to my ears. Decible was neutral but its lack of Itunes integration was a non-starter.
This is with LCD3s and a Meridian Explorer out of a Mac Mini.