I work in an open office plan where there are a lot of distracting conversations. Open earbuds don't isolate enough. Currently I use a pair of Fostex T50RP closed back around-ear headphones. They isolate well enough, but my ears get fatigued after using them for a few hours, probably because of the closed air pressure environment that closed cans give you.
I want something that won't fatigue my ears after the typical 8-10 hour office work day and will keep the noise out. Over-ear cans don't work for me because I wear glasses and they get uncomfortable quickly. All of the noise cancelling cans I've found are closed. Any suggestions?