I think it also depends on how much critical listening you do. In critical listening, you should be able to hear a difference, especially with nice speakers. If you have music in the background while doing other things, you would probably never hear a difference. It also depends on what you listen to. From my onboard soundcard I can't tell the difference between lossless and 128kbps or even 24b/96k versus 128kbps, but I can tell the difference between them using the ODAC and my O2. So, if all your music is compressed, might not help much, but it helped me get the extra quality out of the higher bitrate files. Your mileage may vary.