If you are planning to just use them in a perfectly quiet and nicely setup desktop system, you are looking at one of the least cost effective headphones you can buy.
My customs does not get more use than my desktop system, but when I use them they are going to be music, pure eye shut listening. My home system got more overall use (VOIP, gaming, videos), but far less pure listening time maybe not even half of the pure music listening time compared to my customs.
The additional isolation allows me to listen on the most unthinkable environments for serious listening, I can listen in noisy London Tube, buses and enjoy as much as I am listening on a quiet library or a quiet train.
Sure, you might be able to find universals that can block out just as much (ER4 with Tri-Flange?), but finding one that sounds as good and this comfortable is just impossible. Universals are just not as comfortable and refined as CIEMs. If you don't need the isolation and the long lasting comfort, consider something else. You might save a fair amount.