Out of pure ego, I'll repost something similar I posted on a now locked USB thread some time ago:
There's a gigantic difference between a discovery and an invention. When you say "science has been wrong before" you're talking about discoveries. They are a thing of nature that we study. For example, I can analyze a certain chemical compound and through my results "this is molechule X". And later, though better means and new procedures, another scientist takes an identical sample and determines "the previous observations are incorrect, this is in fact molechule Y". This has happened lots of times along science, a good example is the belief that atoms were spheres with little electrons stuck to them, we now know that model is wrong. All of these things already existed and we simply investigated them, drawing better conclusions each time.
However, with USB it's an invention. It's man-made. I don't think it's quite possible for us to invent something like a data transmission protocol and use it without understanding how it works. I don't know if you ever compiled a program in a computer, but it only works if absolutely everything is perfectly correct, so it's not something that you can type by accident and get any results. What I mean is, these things don't come from throwing science at a wall and see what sticks, they only work because we understand them completely. We know it's impossible for a USB cable to actually change the sound in terms of things like frequency response (or soundstage!) because the way it was intentionally designed does not support that kind of change. It's like saying a car might turn into a transformer, that can't happen by accident, only if you added the machinery for that process.
I still think an invention is a science, or at least required science to be created. But it's not something we try to understand, it's something we can do because we understand it.
I like the video so far =)