For sure, I used to do that with every headphone I've had previously and did it very precisely for every headphone until M-Audio Q40 which have roughly or close enough to my ideal FR balance that EQing isn't worth it unless I'd buy a proper hardware EQ for say $250 or so but I don't feel it would be worth it for a 10-15% or whatever gain in sound quality.
Q40 measures like this according to goldenears site:
So hoping M100 has somewhat similar, I wouldn't say no to slightly more forward lower-midrange (~3dB) as well as better extension in the very upper-end though. Don't mind the 9kHz peak, I did some slight modding & burn-in helped and I can't honestly hear any peak there anymore which I was definitely able to tell when I first listened to them out of box, I don't like peaks like that and I'm glad V-Moda doesn't either. :)
Anyway soundstage is what I'm most interested in hearing an improvement, I tested for example the very underrated Denon HP-700 DJ headphones which is on-ear and comfort is far less than ideal but the soundstage was really nice for a closed/semi-closed headphone but it lacked in subbass extension for my needs, would be nice if M100 would have similar soundstage though.
Edited by RPGWiZaRD - 9/16/12 at 3:50pm